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PoMMax Pomegranate Extract

Full-Spectrum Pomegranate Fruit Extracts
75% Polyphenols, 15% Punicalagins & 2.5% Ellagic Acid

Botanical source: the whole fruits of Punica granatum L.

Chemical constituents: The fruit of Pomegranate is rich in potent polyphenolic antioxidants, particularly ellagitannins: Punicalagins, Punicalin, and Gallic Acid, etc. Punicalagins are unique polyphenols that are found most abundantly in Pomegranate juice. They are therefore viewed as ideal markers for Pomegranate derived products. Punicalagins are metabolized into Ellagic Acid after consumption, and they are considered to be an 'adoptic' precursor for Ellagic Acid, which is only present at low levels (around 1%) as free Ellagic Acid in Pomegranate fruit. Pomegranate extracts with high levels of Ellagic Acid (20%-80%) are generally achieved by adding purified Ellagic Acid from other sources to the extract.

Pharmacology and clinicals: Pomegranate fractions with Ellagic Acid have been extensively studied and noted for their strong anti-cancer and antioxidant activities [1-4]. However, being insoluble in water, Ellagic Acid can only be absorbed and utilized by human body after consumption of Punicalagins as one of their metabolites [1]. It has also been suggested that the anti-cancer and antioxidant benefits of Pomegranate reported by numerous studies derive from the synergistic effects of the full spectrum of components found in the whole fruit, rather than just the Ellagic Acid or other isolated pure chemicals alone [2-4].

Analytical specifications: ProfileProven Full-Spectrum Pomegranate fruit extract is controlled to contain the key compounds present in a whole Pomegranate fruit according to the ideal proportion set by nature to ensure the 100% benefit of the fruit. The content of Total Polyphenols (> 75%) is tested by Folin-Ciocalteau method, and the potencies of Punicalagins (> 15%) and Ellagic acid (> 2.5%) are determined and HPLC analysis. Good Manufacturing Practice (GMP) and standardization of active principals of product ensure that all batches meet specifications.

Remarks:
Extracted by Ethanol (Food Grade) and Distilled Water with an extract ratio of 40:1; non-GMO; ETO-free and non-irradiated.

(*) Representative sample derived from drums of each lot, using the 'square root of N + 1' method (ENI.SOP.E502.7.2). Assay verified at an FDA Registered lab (ENI.SOP.H804.7.1).
(**) Verified by skip lot testing at an FDA certified lab in accordance with ENI testing protocol (ENI.SOP.H804.7.2).
(***) In compliance with California Proposition 65 (< 0.5 ìg/day) based on the typical daily recommendation of 200-400 mg.

Please note: Actual results may vary ± 5% to the specifications due to laboratory test variability.

References:

1. Seeram, N., et al. (2006). Pomegranate Juice Ellagitannin Metabolites Are Present in Human Plasma and Some Persist in Urine for Up to 48 Hours. J. Nutr. 136, 2481-2485.
2. Rimonest Ltd. (2006). Short communication: Be aware of Pomegranates bearing 40% ellagic acid. Journal of Medicinal Food 9 (1), 119-122.
3. Lansky E.P. et al (2005). Pomegranate (Punica granatum) pure chemical show possible synergistic inhibition of human PC-3 prostate cancer cell invasion across Matrigel. Invest New Drugs 23, 121-122.
4. Aqqarwal, B., et al. (2006). Molecular targets of dietary agents for prevention and therapy of cancer. Biochem Pharmacol, 71 (10), 397-421.