ORAC-15,000

15,000 (μmol TE/g) ORAC Value

ORAC-15,000 is a unique and highly concentrated extract of grape skin, seed and fruit. The extract is naturally rich in proanthocyanidins (a group of phenolic compounds) also called OPC's. These compounds contribute to the antioxidant potential and are concentrated to a levels which makes ORAC-15,000 the highest known ORAC value ingredient (a comparison of ORAC value substances is shown below, Table 1 [1-3]).

Botanical source: The seed, skin and fruit of Grape (Vitis vinifera)

• Highest known ORAC value supplement ingredient
• Adds significant anti-oxidant activity to any supplement or beverage
• Supports cardiovascular health
• Excellent water solubility and mild flavor for beverage applications

ORAC value and anti-oxidant capacity: ORAC, the Oxygen Radical Absorbance Capacity system was developed by the USDA to reliably quantify the anti-oxidant capacity of foods and supplement compounds. ORAC is reported in Trolox Equivalents (TE), per one gram of product tested. Trolox is a watersoluble vitamin-E like compound that is used as a standard.

Pharmacology and Clinicals: The compounds in ORAC-15,000 from grape extract are potent antioxidants [5]. They strengthen and protect cell membranes from oxidative damage, provide cardiovascular support and wide ranging health benefits [6].

Analytical Specifications: The antioxidant capacity of ORAC-15,000 is assured by the ORAC (APPH) method, and a value of NLT 15,000 ORAC value is guaranteed. ORAC-15,000 is also required to pass each step of the Ethical Naturals ProfileProven Quality Assurance system which guarantees product purity, potency and integrity.

Recommended Dosage: Recommended ORAC intake (USDA) is around 5,000 units/day, though it is estimated that most people consume less than 3,000 units/day. To achieve 100% of the USDA recommended daily level of ORAC antioxidant, a dose level of 350mg provides a little over 5000 ORAC units [4].

Technical Specification: ProfileProven ORAC-15,000 Grape Extract Version C08-04

Remarks:
Extracted by food grade ethanol and distilled water with an extract ratio of 50:1; no excipients or carriers used; non-GMO; ETO-free and non-irradiated.
(*) Representative sample derived from drums of each lot, using the 'square root of N + 1' method
(ENI.SOP.E502.7.2). Assay verified at an FDA Registered lab (ENI.SOP.H804.7.1).
(**) Verified by skip lot testing at an FDA Registered lab in accordance with ENI testing protocol
(ENI.SOP.H804.7.2).
(***) In compliance with California Proposition 65 (< 0.5 μg/day) based on the typical daily recommendation of 200-300 mg/day based on daily intake of 3000 to 5000 ORAC score.
Please note: Actual results may vary ± 5% to the specifications due to laboratory test variability.

References:

1. Prior, R.L., et al. (1999). Variability in dietary antioxidant related natural products supplements: the need for method standardization. JANA, 2, 46-56.
2. Cao, G., et al. (1996). Antioxidant capacity of tea and common vegetables. J. Agri. Food Chem, 44, 3246-31.
3. Wang, H. et al. (1996). Total antioxidant capacity of fruits. J. Agric. Food Chem 44, 701-5.
4. Mary J. Feeney (2004). Fruits and the prevention of lifestyle-related disease. Clinical and Experimental Pharmacology and Physiology, 31 (s2), S11–S13.
5. M. Balu et al., Rejuvenation of antioxidant system in central nervous system of aged rats by grape seed extract, Neuro Sci Lett., 383 (3), 295-300, 2005.
6. D. Bagchi et al., Free radicals and grape seed proanthocyanidin extract: importance in human health and disease prevention, Toxicology, 148 (2-3), 187-97, 2000.

Table 1.
ORAC Scores of some common dietary supplement products, vegetables and fruits.