Aniracetam (1-Anisoyl-2-pyrrolidinone)

Aniracetam (1-Anisoyl-2-pyrrolidinone) is a fat soluble potent analog of Piracetam. Aniracetam is a nootropic drug of the racetam family. It is lipid soluble and has possible cognition enhancing effects.

Aniracetam is an amino acid-like compound that clinically studies suggest can enhance perception, memory, focus, concentration, and creativity. Aniracetam increases communication between the two hemispheres of the brain and stimulates AMPA and NMDA receptor sites shown to be important in memory formation and concentration. results indicate that aniracetam possesses a wide range of anxiolytic properties, which may be mediated by an interaction between cholinergic, dopaminergic and serotonergic systems.

While it shares many of Piracetam's effects on the brain it has two main unique advantages Piracetam does not have:

• Being fat soluble it has far better penetration into the brain through the blood brain barrier and is longer lasting.
• It is a potent stimulator of the brain's Glutamate AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) receptors.

AMPA receptor research is considering an exciting development in studying and enhancing cognition. Such compounds that effect AMPA receptors are called Ampakines.

Neurochemical Effects:

• Similar to Piracetam, but due to its fat solubility its effects last longer and is far more potent.
• Helps increase communication between your left and right sides of the brain, resulting in improved creatively, perception, and more.
• Positive allosteric modulator of AMPA receptors (Ampakine)
• Enhances glutamatergic neurotransmission, long term potentiation, synaptic transmission, neurotrophin expression, and impulsivity.
• Potentiates alpha 4 beta 2-type nicotinic acetylcholine receptors
• Supprots memory & facilitates dual dopaminergic/serotonergic transmission
• Regulates calcium/calmodulin-dependent protein kinase (CaMKII)
• Elevates memory consolidation
• Modulates Serotonin 5-HT2A and dopamine D2 receptors
• Improves Cerebral Glucose Metabolism
• Has an more potent AMPA receptor enhancing effect than Piracetam, resulting in better focus and concentration.

What works best with it? Piracetam, Oxiracetam, Deprenyl, Hydergine, Centrophenoxine, L-Huperzine A, Idebenone, Pyritinol.