| Niacin (Vitamin B-3) is an essential
B-vitamin necessary for good health. Many Niacin supplements cause a
temporary Niacin flush or tingling red rash on the skin when taken
in large doses. This flush-free Niacin is formulated to avoid such
reactions.
LIKELY USERS:
Those trying to control
cholesterol
KEY INGREDIENT(S): Inositol Hexanicotinate 640
mg
MAIN PRODUCT FEATURES:
Inositol Hexanicotinate is a stable, non-flushing source of
Niacin, a form of Vitamin B-3. This double strength formula provides
500 mg. of niacin (as nicotinic acid) per capsule, along with 135
mg. of inositol. The slow breakdown of this compound means that
blood serum levels of niacin do not reach their maximum until about
ten hours after taking this formula, normally avoiding niacin’s
usual “flushing” effect. The “niacin flush”, a safe but
uncomfortable brief redness, itching and feeling of warmth caused by
larger doses of niacin stimulating the release of histamine in
capillaries near the skin, should not occur with Flush Free Niacin.
Niacin’s actions include regulating cholesterol. It can increase
HDL cholesterol (“good” cholesterol) and decrease triglycerides,
improving the total cholesterol profile. Niacin is utilized by the
body as an essential nutrient for carbohydrate, alcohol and fat
metabolism.
Niacin is also known to improve circulation of blood, especially
peripheral circulatory improvements.
This is a vegetarian formula in a Vcap®.
This formula contains twice the dose of our regular Flush Free
Niacin formula.
OTHER IMPORTANT ISSUES:
Many doctors prefer this form of niacin to time-release niacin
formulas, due to problems with flushing and liver toxicity
associated with the time-release forms.
Inositol is a substance found in grains and a component of
lecithin, also known as phytate, which is used for healthy nerves
and cell membranes. Inositol is also involved in fat metabolism.
AMOUNT TO USE: One or more Vcaps a day,
preferably with meals.
SYNERGISTS: B-complex vitamins, garlic, fish
oil, flax oil, olive oil, fiber, lecithin, plant sterols (phytosterols)
and sterolins, Vitamin E (mixed tocopherols and tocotrienols), nuts,
policosanols, chromium, Vitamin C, pantethine (a form of Vitamin
B-5)
CAUTIONS:
People using very high doses of niacin
under a doctor’s supervision to reduce cholesterol should be
monitored for proper liver function and also take a B-Complex
formula to avoid increasing their levels of homocysteine, a
potentially harmful metabolite. Niacin should not be used by
pregnant women, nursing mothers, people with stomach ulcers,
diabetics or those with liver problems unless recommended under the
supervision of a healthcare professional. Please notify your
physician about your supplement use if you are using any drugs!
REFERENCES
Ring EFJ, Porto LO, Bacon PA. Quantitative thermal imaging to
assess inositol nicotinate treatment for Raynaud's syndrome. J Int
Med Res. 1981;9:393-400.
O'Hara J, Jolly PN, Nicol CG. The therapeutic efficacy of
inositol hexanicotinate (Hexopal®) in intermittent claudication: A
controlled trial. Br J Clin Pract. 1988;42:377-383.
Murphy R. The effect of inositol hexanicotinate (Hexopal) in
patients with Raynaud's syndrome. Clin Trials J. 1985;22:521-529.
Kiff RS. Does inositol hexanicotinate (Hexopal) influence
intermittent claudication? Br J Clin Pract. 1988;42:141-145.
Head A. Treatment of intermittent claudication with inositol
nicotinate. Practitioner. 1986;230:49-54.
Eur J Clin Pharmacol. 1979 Aug;16(1):11-5. Nocturnal inhibition
of lipolysis in man by nicotinic acid and derivatives. Kruse W,
Kruse W, Raetzer H, Heuck CC, Oster P, Schellenberg B, Schlierf G.
PMID: 499296 [PubMed - indexed for MEDLINE]
Welsh AL, Ede M. Inositol hexanicotinate for improved nicotinic
acid therapy. Int Record Med. 1961;174:9-15.
Hammerl H, Kraenzyl CH, Sudlar M. Metabolic studies for
determination of the action mechanism of a ß-sympathometic. Wein
Klin Woschenschr. 1968;80:269.
Sommer H. Nicotinic acid levels in the blood and fibrinolysis
under the influence of the hexanicotinic ester of m-inositol.
Arzneim Forsch. 1975;15:1337.
Dorner VG, Fischer FW. The influence of m-inositol hexanicotinate
ester on the serum lipids and lipoproteins. Arzneim Forsch.
1961;11:110-113.
El-Eneim AMA, Hafez YS, Salem H, Abdel M. The role of nicotinic
acid and inositol hexanicotinate as anticholesterolemic and
antilipemic agents. Nutr Reports Int. 1983;28:899-911.
Mercier J, Gavend MR, Dessaigne S. Effect of inositol and its
derivatives on hypercholesterolemic rabbits. Cong Union Therap
Intern (Brussels). 1963;8:11.
Kruse W, Kruse W, Raetzer H, et al. Nocturnal inhibition of
lipolysis in man by nicotinic acid and derivatives. Eur J Clin
Pharmacol. 1979;16:11-15.
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Amino Acids
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