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Numerous double-blind placebo-controlled studies involving a total of more than 1,300 participants show that ipriflavone can slow the progression of osteoporosis, and perhaps even reverse it to some extent.

For example, a 2-year double-blind study followed 198 postmenopausal women who showed evidence of bone loss. At the end of the study, there was a gain in bone density in the ipriflavone group, while people in the placebo group lost bone mass. Numerous other studies have found similar results.