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I3C helps to regulate cell growth rates, and helps to change a strong and inflammatory form of estrogen (estradiol) into a safer, less aggressive form (estrone). In technical terms, I3C influences our bodies to favor the 2-hydroxylation metabolic pathway to increase the ratio of 2-hydroxysterone to 16a-hydroxyestrone. It may also be able to influence estradiol activity in neighboring cells to also be less aggressive at triggering cell growth. The regulation of estrogen-related cell growth is considered a factor into whether one is more prone to develop certain cancers, so dietary nutrients that normalize cell growth are considered protective. Cells need to be able to repair and grow at normal rates. Uncontrolled growth can be very dangerous. I3C helps trigger cell death in abnormal cells so they won’t become a bigger problem over time.

Other studies indicate that I3C has the same protective effects for testosterone and other androgenic hormones as for estrogens. This means that it’s protective for both men and women.

I3C is also an antioxidant that protects cells from harmful bacteria that can make cells behave erratically or become harmful to the body. It may also protect cells against the effects of dioxin and other estrogenic compounds found in pesticides, plastics and other chemical sources. In some studies it has even been protective against known carcinogens, protecting both prostate and breast tissues. I3C has also shown that it may protect DNA from chemical damage. NOW FOODS Indole 3 Carbinol in packaged in Glass bottles to protect this fragile material.