Damiana was recorded to be used as an aphrodisiac in the ancient Mayan civilization, as well as for "giddiness and loss of balance." A Spanish missionary first reported that the Mexican Indians made a drink from the Damiana leaves, added sugar, and drank it for its purported power to enhance lovemaking.

Damiana has a long history of use in traditional herbal medicine throughout the world. It is thought to act as an aphrodisiac, antidepressant, tonic, diuretic, cough-suppressant, and mild laxative. It has been used for such conditions as depression, anxiety, sexual inadequacy, debilitation, bed-wetting, menstrual irregularities, gastric ulcers, and constipation. In Mexico, the plant also is used for asthma, bronchitis, neurosis, diabetes, dysentery, dyspepsia, headaches, paralysis, nephrosis, spermatorrhea, stomachache, and syphilis.