What do COX-2 and 5-LOX have to do with pain?

Scientific research has defined naturally occurring enzymes known as Cyclooxygenase-2 (COX-2) and 5-Lipoxygenase (5-LOX) which are implicated in a number of inflammatory conditions. Unlike its more benign and protective sister COX-1 the harmful COX- 2 enzyme is present only during periods of inflammation. COX-2 and 5-LOX form the destructive duo responsible for the production of the proinflammatory type of mediators called eicocasonoids; specifically prostaglandins PGE-2 and leukotrienes.

Those suffering with pain have used non-steroidal anti-inflammatory drugs (NSAIDS) that are available over the counter for years. These medications work by inhibiting the formation of the COX enzymes. The problem is that the NSAIDS block both the harmful COX-2 and the helpful COX-1 enzymes. The COX-1 enzyme functions as a protective mechanism for stomach lining. Long term inhibition of this vital COX-1 enzyme by overuse of these drugs has caused many gastric disorders including bleeding ulcers.

Thankfully at the beginning of time our Creator designed plants that naturally help us with the pain caused by inflammation. These plants have been used for generations by the native peoples of various Eastern and Southeastern countries. Over time, researchers have discovered natural compounds in a number of different plant sources that can significantly support the body’s response to inflammatory conditions.

Holy Basil Extract (Ocimum sanctum)
Holy Basil is an annual herb native to India. Considered a sacred herb by the Hindus, it’s used in Ayurvedic medicine for a number of different conditions. Holy Basil contains the natural compound ursolic acid, which helps to support immune system function and has proven useful in dealing with COX-2 & 5-LOX.

Turmeric Extract (Curcuma longa)
Turmeric is a perennial plant found primarily in southern and eastern Asia. It’s one of the most popular and widely used herbs in Ayurvedic medicine. The active component in Turmeric is curcumin, which is a potent antioxidant compound that provides outstanding benefits when dealing COX-2 & 5-LOX.

Ginger Extract (Zingiber officinale)
One of the most popular and widely used herbs today, Ginger is an important part of many different Asian medical systems. Primarily used to detoxify the body and calm an upset stomach, Ginger also supports circulation and has a beneficial effect on COX-2 & 5-LOX.

Green Tea (Camellia sinensis)
Widely distributed throughout southern Asia, Green Tea is also found in Africa. It contains a veritable treasure trove of antioxidant compounds, including polyphenols, which support immune system function. Research shows that one particular polyphenol, epigallocatechin gallate (EGCG), is over 200 times more powerful than vitamin E!

Boswellin (Boswellia serrata)
This large tree is native to India and yields a gummy resin with a wide variety of applications. One of the most well-used herbs in Ayurvedic medicine, Boswellin contains boswellic acids, which support healthy circulation and work to deactivate certain chemical triggers often associated with COX-2 & 5-LOX.

Bromelain
Bromelain is a compound extracted from pineapples that research shows has a number of beneficial effects in dealing with COX-2 & 5-LOX. Bromelain works by breaking down and removing proteins in inflamed tissues.

D-Flame also contains Baikal Skullcap, Resveratrol and Berberine, other natural compounds with proven benefits. You can pay more with other companies for a comparable product, but why would you? NOW’s quality and affordability allow you to remain competitive while keeping your customer’s pocket book and satisfaction in mind. They’ll thank you for it!